Drug Synergy
MuSyC quantifies synergy of potency (horizontal axis) and synergy of efficacy (vertical axis)
Many diseases require combinations of multiple drugs for effective treatment. I am interested in identifying, quantifying, and understanding synergistic or antagonistic interactions between drugs in combinations.
A web application for calculating MuSyC synergy parameters for combinations is now available! https://musyc.lolab.xyz/
Publications
synergy - A Python library for calculating, analyzing, and visualizing drug combination synergy
Combinations of multiple pharmacological agents can achieve a substantial benefit over treatment with single agents alone. Combinations …
Charting the Fragmented Landscape of Drug Synergy
Even as the clinical impact of drug combinations continues to accelerate, no consensus on how to quantify drug synergy has emerged. …
A Consensus Framework Unifies Multi-Drug Synergy Metrics
Drug combination discovery depends on reliable synergy metrics; however, no consensus exists on the appropriate synergy model to …
Quantifying Drug Combination Synergy along Potency and Efficacy Axes
Two goals motivate treating diseases with drug combinations: reduce off-target toxicity by minimizing doses (synergistic potency) and …
